My viewing needs are pretty simple on my Mac. I bonded early on with FFView and have stuck with it. I also have Simple Comic loaded, but always go back to FFView. Were I to acquire an iPad, I might well explore other options...
And, as I can't say often enough at every juncture, my eternal thanks to the comic owners (especially JVJ) and scanners for this wonderful site. I've done my best to fill in some holes from my own limited collection, but I am way in debt to the powerhouse scanners out there. My motto: scan at 300dpi, at a minimum. I'm betting that resolution on monitors and pads will continue to climb in the future, to the point that scans at anything less than that will look unbelievably crude. But, I'm getting off-topic. Sorry! ;-)