Radar, the International Policeman, in Fawcett's Master Comics, fought drug smugglers a time or two. I don't think the exact drugs were specifically identified. I'm pretty certain actual drug use was not shown.
Circa 1938 The Secret Agent X pulp magazine gave us "Curse of the Mandarin's Fan." The story told how the Opium gangs warred with the Marijuana gang to see which would be the only addictive drug sold in San Francisco. The author gave the impression that the two drugs had exactly the same Reefier Madness effect on all users.